Sassuolo Calcio vs Lazio Rome 27 October 2026 Prediction

Lazio have yet to drop a point away from home in the league. Gennaro Gattuso’s side will look to extend that run in Reggio Emilia, though they have lost three of their last five road games against Sassuolo.

Sassuolo’s Form Has Slipped

Sassuolo initially appeared to be adjusting well to their change of manager, but they have taken just one point from their last four Serie A games. That stretch includes losses to Frosinone (4-2) and Monza (2-1), as well as a 2-0 defeat to Como and a 1-1 draw with Milan. Under Alberto Aquilani, Sassuolo build from the back with short passes, but turnovers have left them vulnerable to opponents that press well.

As they did under Fabio Grosso, Sassuolo attack primarily down the wings, relying on Domenico Berardi and Armand Laurienté, or their replacements, Volpato and Domínguez. They also leave space for counterattacks when they lose possession. Their defense has struggled to cover that space, particularly with defender Fedde Leysen and defensive midfielder Ismaël Koné sidelined by long-term injuries.

Lazio Remain Near the Top

After eight rounds, Lazio trail league leaders Inter only on tiebreakers. Gattuso’s team has conceded a league-low five goals while combining organized defending with aggressive pressing and quick, direct attacks. They still have trouble breaking down set defenses. Even so, Lazio beat Parma 2-1 in their last game despite having an uncharacteristic 68% of possession.

Injuries have not stopped Lazio from winning. Nicolò Rovella, Albert Guðmundsson and Adam Marušić would all be contenders to start if healthy. Reda Belahyane, Tijjani Noslin and Romano Floriani Mussolini have performed well in their absence.

Sassuolo vs Lazio Predicted Lineup

Sassuolo (4-3-3): Turati; Cinquegrano, Ćaleta-Car, Odenthal, Doig; Lipani, Matić, Thorstvedt; Berardi, Esposito, Laurienté.

Out: Boloca, Pieragnolo, I. Koné, Leysen, Y. Paz, Idzes (all injured).

Manager: Alberto Aquilani.

Lazio (4-3-3): Mandas; Floriani, Šutalo, Provstgaard, Tavares; Taylor, Belahyane, Frattesi; Isaksen, Noslin, Zaccagni.

Out: Marušić, Rovella, Guðmundsson (all injured); Pinamonti (questionable).

Manager: Gennaro Gattuso.

Sassuolo vs Lazio Prediction: Lazio to Win

Main pick: Lazio are the favorites on current form. Sassuolo have lost three of their last four Serie A games, and their short-passing approach from the back could give Lazio’s press opportunities to win possession in dangerous areas. The pick is Lazio to win at 2.25.

Goals pick: Lazio have scored at least twice in six straight league games. Sassuolo’s home games in the 2026/27 season have averaged exactly two goals per game, so a higher-risk option is over 3.5 total goals at 2.68.