Philadelphia 76ers vs Detroit Pistons 25 October 2026 Prediction

Philadelphia is unbeaten to start the season with LeBron James and Brown in the lineup. The 76ers face the Bucks before meeting the Pistons, who finished first in the Eastern Conference last regular season. Detroit will try to hand Philadelphia its first loss.

Maxey Leads Philadelphia

The 76ers have one of the league’s strongest starting lineups, though an unnamed scout has expressed doubts about Embiid. Carmelo Anthony considers Maxey Philadelphia’s most important player, despite the bigger names around him.

Philadelphia opened the season with wins over the Knicks (106-100) and Cavaliers (114-106). Still, the 76ers rank outside the league’s top 20 in field-goal percentage at 43.6%. Maxey has scored 60 points across those two games.

Philadelphia Predicted Lineup: Maxey, Edgecombe, Brown, James, Embiid

Out: Barlow and Hukporti (injuries)

Manager: Nick Nurse

Detroit’s Ball Movement

The Pistons came back from 22 points down against the Celtics in their 2026-27 season opener. They followed that with a convincing win over the Heat, leading 51-26 after the first quarter. Detroit is averaging 30.5 assists through two games, a top-three mark in the league.

Six Pistons scored at least 10 points against Miami. Collins had 23 points and seven rebounds, while Reed added 19 points and 11 rebounds. Their production inside could matter against Philadelphia, which ranks near the middle of the league with 44.5 rebounds per game.

Detroit Predicted Lineup: Cunningham, Robinson, Thompson, Collins, Reed

Out: None

Manager: J.B. Bickerstaff

Detroit Won All Four Meetings Last Season

The Pistons won all four regular-season games against Philadelphia last season: 111-108, 114-105, 131-109 and 116-93. The 76ers won their Summer League meeting 101-93.

Philadelphia 76ers vs Detroit Pistons Prediction: Detroit Pistons to Win

Main prediction: Philadelphia has beaten the Knicks and Cavaliers, but it plays Milwaukee before this game. Embiid often sits out one game of a back-to-back, and it is unclear whether James will play on consecutive nights. The 76ers also rely heavily on their starters for scoring; their 94 points rank among the league’s top three starting lineups. Detroit has kept most of the roster that went 60-22 in 2025-26 and looked sharper against Miami than it did in its opener against Boston. The pick is a Detroit Pistons win.

Team total prediction: Detroit has allowed at least 111 points in each of its first two games, but Philadelphia has yet to score more than 114. Embiid, James and Edgecombe are each shooting below 39% from the field, and the back-to-back could make it harder for the 76ers to improve offensively. The pick is Philadelphia 76ers team total under 110.5.

This prediction will be updated after Philadelphia vs Milwaukee.